Peer-Reviewed Publications

Chen L, Grieco DL, Beloncle F, Chen GQ, Tiribelli N, Madotto F, Fredes S, Lu C, Antonelli M, Mercat A, Slutsky AS, Zhou JX, Brochard L.

Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study.

Intensive Care Med 2022; 48: 888–898.

Burns KEA, Stevenson J, Laird M, Adhikari NKJ, Li Y, Lu C, He X, Wang W, Liang Z, Chen L, Zhang H, Friedrich JO.

Non-invasive ventilation versus invasive weaning in critically ill adults: a systematic review and meta-analysis.

Thorax 2021; 76: 604–611.

Urner M, Mitsakakis N, Vorona S, Chen L, Sklar MC, Dres M, Rubenfeld GD, Brochard LJ, Ferguson ND, Fan E, Goligher EC.

Identifying Subjects at Risk for Diaphragm Atrophy During Mechanical Ventilation Using Routinely Available Clinical Data.

Respiratory Care 2021; 66: 551–558.

Mellado Artigas R, Damiani LF, Piraino T, Pham T, Chen L, Rauseo M, Telias I, Soliman I, Junhasavasdikul D, Santis C, Smith OM, Goligher E, Comtois N, Sinderby C, Heunks L, Brochard L.

Reverse Triggering Dyssynchrony 24 h after Initiation of Mechanical Ventilation.

Anesthesiology 2021; 134: 760–769.

Sklar MC, Madotto F, Jonkman A, Rauseo M, Soliman I, Damiani LF, Telias I, Dubo S, Chen L, Rittayamai N, Chen GQ, Goligher EC, Dres M, Coudroy R, Pham T, Artigas RM, Friedrich JO, Sinderby C, Heunks L, Brochard L.

Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients.

Crit Care 2021; 25: 26.

Pan C, Chen L, Lu C, Zhang W, Xia JA, Sklar MC, Du B, Brochard L, Qiu H.

Lung Recruitability in SARS-CoV-2-Associated Acute Respiratory Distress Syndrome: A Single-Center, Observational Study.

Am J Respir Crit Care Med 2020; 201: 1294–1297.

Chen L, Del Sorbo L, Grieco DL, Junhasavasdikul D, Rittayamai N, Soliman I, Sklar MC, Rauseo M, Ferguson ND, Fan E, Richard JM, Brochard L.

Potential for Lung Recruitment Estimated by the Recruitment-to-Inflation Ratio in Acute Respiratory Distress Syndrome. A Clinical Trial.

Am J Respir Crit Care Med 2020; 201: 178–187.

Grieco DL, Bongiovanni F, Chen L, Menga LS, Cutuli SL, Pintaudi G, Carelli S, Michi T, Torrini F, Lombardi G, Anzellotti GM, De Pascale G, Urbani A, Bocci MG, Tanzarella ES, Bello G, Dell'Anna AM, Maggiore SM, Brochard L, Antonelli M.

Respiratory physiology of COVID-19-induced respiratory failure compared to ARDS of other etiologies.

Crit Care 2020; 24: 529.

Bastia L, Engelberts D, Osada K, Katira BH, Damiani LF, Yoshida T, Chen L, Ferguson ND, Amato MBP, Post M, Kavanagh BP, Brochard L.

Role of PEEP and Regional Transpulmonary Pressure in Asymmetrical Lung Injury.

Am J Respir Crit Care Med 2020; 201: 1569–1572.

Coudroy R, Vimpere D, Aissaoui N, Younan R, Bailleul C, Couteau-Chardon A, Lancelot A, Guerot E, Chen L, Brochard L, Diehl JL.

Prevalence of Complete Airway Closure According to Body Mass Index in Acute Respiratory Distress Syndrome: Pooled Cohort Analysis.

Anesthesiology 2020; 133: 867–878.

Mukhopadhyay SK, Zara M, Telias I, Chen L, Coudroy R, Yoshida T, Brochard L, Krishnan S.

A Singular Spectrum Analysis-Based Data-Driven Technique for the Removal of Cardiogenic Oscillations in Esophageal Pressure Signals.

IEEE J Transl Eng Health Med 2020; 8: 3300211.

Telias I, Junhasavasdikul D, Rittayamai N, Piquilloud L, Chen L, Ferguson ND, Goligher EC, Brochard L.

Airway Occlusion Pressure as an Estimate of Respiratory Drive and Inspiratory Effort During Assisted Ventilation.

Am J Respir Crit Care Med 2020; 201: 1086–1098.

Coudroy R, Lu C, Chen L, Demoule A, Brochard L.

Mechanism of airway closure in acute respiratory distress syndrome: a possible role of surfactant depletion.

Intensive Care Med 2019; 45: 290–291.

Chen L, Del Sorbo L, Grieco DL, Shklar O, Junhasavasdikul D, Telias I, Fan E, Brochard L.

Airway Closure in Acute Respiratory Distress Syndrome: An Underestimated and Misinterpreted Phenomenon.

Am J Respir Crit Care Med 2018; 197: 132–136.

Yoshida T, Amato MBP, Grieco DL, Chen L, Lima CAS, Roldan R, Morais CCA, Gomes S, Costa ELV, Cardoso PFG, Charbonney E, Richard JM, Brochard L, Kavanagh BP.

Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury.

Am J Respir Crit Care Med 2018; 197: 1018–1026.

Guerin C, Beuret P, Constantin JM, Bellani G, Garcia-Olivares P, Roca O, Meertens JH, Maia PA, Becher T, Peterson J, Larsson A, Gurjar M, Hajjej Z, Kovari F, Assiri AH, Mainas E, Hasan MS, Morocho-Tutillo DR, Baboi L, Chretien JM, Francois G, Ayzac L, Chen L, Brochard L, Mercat A.

A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study.

Intensive Care Med 2018; 44: 22–37.

Sun XM, Chen GQ, Chen K, Wang YM, He X, Huang HW, Luo XY, Wang CM, Shi ZH, Xu M, Chen L, Fan E, Zhou JX.

Stress Index Can Be Accurately and Reliably Assessed by Visually Inspecting Ventilator Waveforms.

Respiratory Care 2018; 63: 1094–1101.

Huang HW, Sun XM, Shi ZH, Chen GQ, Chen L, Friedrich JO, Zhou JX.

Effect of High-Flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy and Noninvasive Ventilation on Reintubation Rate in Adult Patients After Extubation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Intensive Care Med 2018; 33: 609–623.

Chen L, Chen GQ, Shore K, Shklar O, Martins C, Devenyi B, Lindsay P, McPhail H, Lanys A, Soliman I, Tuma M, Kim M, Porretta K, Greco P, Every H, Hayes C, Baker A, Friedrich JO, Brochard L.

Implementing a bedside assessment of respiratory mechanics in patients with acute respiratory distress syndrome.

Crit Care 2017; 21: 84.

Rittayamai N, Beloncle F, Goligher EC, Chen L, Mancebo J, Richard JM, Brochard L.

Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort.

Ann Intensive Care 2017; 7: 100.

Burns KEA, Soliman I, Adhikari NKJ, Zwein A, Wong JTY, Gomez-Builes C, Pellegrini JA, Chen L, Rittayamai N, Sklar M, Brochard LJ, Friedrich JO.

Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis.

Crit Care 2017; 21: 127.

Sklar MC, Burns K, Rittayamai N, Lanys A, Rauseo M, Chen L, Dres M, Chen GQ, Goligher EC, Adhikari NKJ, Brochard L, Friedrich JO.

Effort to Breathe with Various Spontaneous Breathing Trial Techniques. A Physiologic Meta-Analysis.

Am J Respir Crit Care Med 2017; 195: 1477–1485.

Chen L, Jonkman A, Pereira S, Cong L, Brochard L.

Driving pressure monitoring during acute respiratory failure in 2020.

Curr Opin Crit Care 2021; 27: 303–310.

Hedenstierna G, Chen L, Brochard L.

Airway closure, more harmful than atelectasis in intensive care?

Intensive Care Med 2020; 46: 2373–2376.

Coudroy R, Chen L, Pham T, Piraino T, Telias I, Brochard L.

Acute Respiratory Distress Syndrome: Respiratory Monitoring and Pulmonary Physiology.

Semin Respir Crit Care Med 2019; 40: 66–80.

Junhasavasdikul D, Telias I, Grieco DL, Chen L, Gutierrez CM, Piraino T, Brochard L.

Expiratory Flow Limitation During Mechanical Ventilation.

Chest 2018; 154: 948–962.

Henderson WR, Chen L, Amato MB, Brochard LJ.

Fifty Years of Research in ARDS. Respiratory Mechanics in Acute Respiratory Distress Syndrome.

Am J Respir Crit Care Med 2017; 196: 822–833.

Grieco DL, Chen L, Dres M, Brochard L.

Should we use driving pressure to set tidal volume?

Curr Opin Crit Care 2017; 23: 38–44.

Grieco DL, Chen L, Brochard L.

Transpulmonary pressure: importance and limits.

Ann Transl Med 2017; 5: 285.

Mauri T, Yoshida T, Bellani G, Goligher EC, Carteaux G, Rittayamai N, Mojoli F, Chiumello D, Piquilloud L, Grasso S, Jubran A, Laghi F, Magder S, Pesenti A, Loring S, Gattinoni L, Talmor D, Blanch L, Amato M, Chen L, Brochard L, Mancebo J.

Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives.

Intensive Care Med 2016; 42: 1360–1373.

Li HL, Zhou JX, Chen L.

Lung Volumes and Volumetric Capnography.

In: Bellani G, editor. Mechanical Ventilation from Pathophysiology to Clinical Evidence. Springer 2022; p. 377–386.

Yoshida T, Chen L, Coudroy R, Brochard L.

Identifying and Applying Best PEEP in Ventilated Critically Ill Patients.

In: Cardiopulmonary Monitoring: Basic Physiology, Tools, and Bedside Management. Springer 2021.

Lu C, Philips N, Chen L.

Monitoring respiratory mechanics.

In: ERS Practical Handbook of Invasive Mechanical Ventilation. European Respiratory Society 2019.

Chen L, Brochard L.

Lung volume assessment in acute respiratory distress syndrome.

Curr Opin Crit Care 2015; 21: 259–264.

Li HL, Chen L, Brochard L.

Protecting lungs during spontaneous breathing: what can we do?

J Thorac Dis 2017; 9: 2777–2781.

Chen L, Li HL, Brochard L.

High-flow nasal cannula in postextubation management.

J Thorac Dis 2016; 8: E1013–E1016.

Chen L, Sklar M, Dres M, Goligher EC.

Different Definitions of Lung Recruitment by Computed Tomography Scan.

Am J Respir Crit Care Med 2016; 193: 1314–1315.